S55746 (Servier 1)
Our first collaboration with Servier started in 2007 and has progressed well over the last eight years. Bcl-2 is the most advanced programme from this collaboration, with S55746, a selective Bcl-2 inhibitor, the first drug candidate stemming from an ongoing collaboration between Vernalis and Servier aimed at discovering anticancer drug candidates selective for individual Bcl-2 family members.
S55746 entered a Phase I study in June 2014, triggering a €1 million milestone payment to Vernalis. Servier has subsequently licensed the development and commercialisation rights to Novartis. Vernalis' commercial terms remain unchanged and so will continue to receive fees from Servier for research as well as sums for achieving research and clinical milestones, together with a potential share of eventual commercial sales through royalties.